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Fudan University 79.6% urine samples from school aged children – Sohu news 9c8814

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Fudan University: 79.6% school children urine detection antibiotics – Sohu news reporter Chen Liyu morning news yesterday, Fudan University announced a new study revealed that childhood antibiotic exposure may be one of the risk factors of childhood obesity. Expert monitoring at Fudan School of public health found that 79.6% of the school-age children in Shanghai detected one or more of the 21 antibiotics. The study found that more than 1 kinds of antibiotics were found in the urine in the frequency of 58.3%, at least two or more antibiotics or antibiotic class also found in the urine frequency were 26.7% and 23.5%, and most were simultaneously detected in 4 categories of 6 kinds of antibiotics in a urine sample; urine total antibiotic concentration and between 0.1-20 ng per milliliter of urine samples accounted for 47.8%, the partial sample concentration above 1000 ng per milliliter of antibiotics. The results showed that children in Jiangsu, Zhejiang and Shanghai were generally exposed to low dose antibiotics. The team believes that this widespread exposure may aggravate bacterial resistance, thereby threatening clinical treatment, and may also pose a potential hazard to children’s growth and development and to the health of the population. The researchers also detected the content of antibiotics found in children and children in the environment and food for years, indicating that the abuse of antibiotics is not only a problem of clinical treatment, but also an important source of antibiotics for children. The research group collected in the Shanghai region in 2013 586 aged 8 to 11 years old children urine sample study results in urine contains 21 kinds of antibiotics, including 5 kinds of macrolide antibiotics, 2 beta lactam antibiotics, 3 tetracyclines, 4 quinolone antibiotics, 4 3 kinds of sulfonamides and chloramphenicol antibiotics, of which 79.6% of school-age children in urine were detected in one or more of the above 21 kinds of antibiotics. To clarify the relation between antibiotics and obesity, according to researchers in the urine of veterinary antibiotics concentration of children from low to high 3 groups, after adjusting for gender and age, parents’ education level, income level, food intake, smoking status and other factors, compared with the low concentration group of children in the high concentration group, the risk of childhood obesity is the low concentration group of 1.99 to 3 times; the research group also believes that the environmental source of veterinary antibiotics, may enter the human body mainly through contaminated water and food. The use of medical antibiotics is essentially short-term high dose exposure, while exposure to antibiotics from food or the environment is a long-term low dose exposure. Exposure patterns of antibiotics may be one of the important factors that affect their lipogenesis. The group said that in 2013, China used 162 thousand tons of antibiotics, accounting for half of the world’s consumption, of which 52% were veterinary, 48% were used, more than 50 thousand tons of antibiotics were discharged into the water and soil environment. The use of antibiotics in aquaculture is a controversial issue, and the Ministry of agriculture has issued a direct ban on the use of antibiotics in 4 kinds of food animals". Yesterday, Wang Na and Wang Hexing, experts at the school of public health at Fudan University, revealed that the antibiotic exposure was currently under way for health.

复旦大学:79.6%学龄儿童尿液检出抗生素-搜狐新闻  记者 陈里予   晨报讯 昨天,复旦大学公布了一项最新研究揭示,儿童时期抗生素暴露可能是儿童肥胖的危险因素之一。复旦公共卫生学院的专家监测发现,79.6%的上海学龄儿童尿液中检出21种抗生素中的一种或几种。   研究发现,1种以上抗生素在尿中被发现的频率为58.3%,至少两种及以上抗生素或抗生素类别在尿中同时发现的频率分别为26.7%和23.5%,而且在一份尿样中最多能同时检测出4类6种抗生素; 尿中抗生素总浓度之和在每毫升0.1-20纳克之间的尿样占47.8%,部分尿样抗生素浓度超过每毫升1000纳克。   该结果表明苏浙沪地区儿童普遍暴露于低剂量抗生素。课题组认为,这种广泛暴露状态可能加重细菌耐药,从而威胁临床治疗,也可能对儿童的生长发育与人群健康造成潜在的危害。研究人员还从儿童体内检测出临床已经停用多年、但在环境和食品中经常发现的抗生素含量,可见抗生素滥用不仅是临床治疗的问题,环境与食品也是儿童抗生素的重要暴露源。   课题组对2013年采集到的上海地区的586名8至11岁学龄儿童尿样进行研究,结果测定出尿中含有21种抗生素,包括5种大环内酯类抗生素、2种β-内酰胺类抗生素、3种四环素类抗生素、4种喹诺酮类抗生素、4种磺胺类抗生素和3种氯霉素类抗生素,其中79.6%的学龄儿童尿液中检出上述21种抗生素中的一种或几种。   为搞清楚抗生素与肥胖的关系,研究人员按照尿中兽用抗生素浓度将儿童分为由低到高3个组,在校正了性别、年龄、家长的教育程度、收入水平、膨化食品摄入、亲友的吸烟状况等因素后,与低浓度组的儿童相比,中、高浓度组的儿童肥胖风险是低浓度组的1.99倍至3倍;课题组还认为,兽用抗生素的环境来源,可能主要通过污染水及食物进入人体。医用抗生素使用实质上是短期高剂量暴露,而来自食品或环境中的抗生素暴露是长期低剂量暴露,抗生素的暴露模式可能是影响其促进脂肪生成的重要因素之一。   课题组表示,2013年中国抗生素使用一年达16.2万吨,约占世界用量的一半,其中52%为兽用,48%为人用,超过5万吨抗生素被排放进入水土环境中。在养殖行业,抗生素的使用是颇有争议的问题,农业部已发布公告直接禁止了食品动物的4种“抗生素使用”。   昨天,复旦大学公共卫生学院专家王娜、王和兴透露,目前正在进一步研究抗生素暴露对健康有多大影响,以及应采取什么措施加以抑制。相关的主题文章:


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